What does tolerance indicate in substance use?

Tolerance in the context of substance use refers to the body's adaptation to a substance over time, resulting in the need for larger amounts to achieve the same desired effect. This phenomenon occurs as the body becomes accustomed to the presence of the substance, leading to a diminished response to its effects. As a result, individuals may find that the initial amount they consumed no longer produces the same outcomes, prompting them to increase their dosage to attain the desired impact. This is a critical aspect of substance use disorders, as increased tolerance can contribute to patterns of escalating use and dependency. Understanding tolerance is essential for recognizing the physiological changes associated with substance use and for developing appropriate treatment approaches.