Which of the following symptoms indicates opioid withdrawal?

Lacrimation, or excessive tearing, is indeed a common symptom of opioid withdrawal. When someone who is dependent on opioids suddenly reduces or stops their intake, the body reacts to the absence of the drug. This reaction manifests in various physical and psychological symptoms, one of which includes increased secretion of tears.

Opioid withdrawal tends to produce a range of symptoms as the body struggles to regain balance after the cessation of drug use. These symptoms can include agitation, anxiety, nausea, vomiting, diarrhea, sweating, and lacrimation, among others. The presence of excessive tears in these cases reflects the physical distress that can accompany withdrawal.

Other symptoms listed, such as euphoria, are typically associated with opioid use rather than withdrawal, where individuals often experience dysphoria or depression instead. Confusion can occur but isn't specifically indicative of opioid withdrawal compared to other drugs or conditions. Muscle weakness may present in various situations but is not a hallmark symptom of opioid withdrawal. Hence, lacrimation stands out as a clear sign of opioid withdrawal, making it the correct choice.